Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 19, Issue 33, Pages 5891-5905Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b902208b
Keywords
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Funding
- Korea Research Foundation [KRF-2008-C00590]
- Korean government [R11-2005-008-00000-0, R01-2007-00020141-0]
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A reverse thermogelling polymer aqueous solution is a free-flowing sol at a low temperature and becomes a semisolid gel as the temperature increases. It is expected to be a very promising biomaterial as a minimally invasive injectable system for drug delivery and tissue engineering applications. The principles of materials design are (1) balancing the hydrophobicity and hydrophilicty of a polymer, (2) controlling the topology of a polymer, (3) matching the degradation kinetics of a polymer with a specific biomedical application, and (4) controlling the biocompatibility of the material with a drug as well as a host. This article covers recent progress of reverse theromogelling biodegradable polymers based on aliphatic polyesters, polyphosphazenes, poloxamer derivatives, polysaccharides, polypeptides, poly(propylene phosphate)s, polyorthoesters, polycarbonates, polycyanoacrylates, and poly( N-(2-hydroxyethyl) methacrylamide-lactate) s. The material characteristics, driving forces or mechanism for sol-gel transition, and their biomedical applications are summarized. In addition, the authors' perspectives on future reverse theromogelling materials design are suggested.
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