Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 19, Issue 16, Pages 2328-2335Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b815836c
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Funding
- regional council of Rhone-Alpes (France)
- Agence Nationale de la Recherche [ANR-05-NANO-037-02]
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The cytotoxicity of luminescent paramagnetic gadolinium oxide nanoparticles activated by harmless thermal neutron irradiation was evaluated on a luciferase coding gene transfected lymphome cells (EL4-Luc). Cellular uptake of nanoparticles was determined by fluorescence and magnetic resonance imaging and by ICP-MS analyses while the metabolic activity of irradiated EL4-Luc cells was monitored by bioluminescence. The alteration of the irradiated cells depends both on neutron irradiation dose and on gadolinium content within cells. In addition to their dual modality imaging ability, the application of these multifunctional particles for neutron capture therapy can be envisaged.
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