Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 18, Issue 11, Pages 1204-1208Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b718745a
Keywords
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Funding
- NATIONAL CANCER INSTITUTE [R01CA105452, R01CA095164] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES015739] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA095164, R01 CA105452-04, R01 CA095164-05S1, R01 CA105452] Funding Source: Medline
- NIEHS NIH HHS [R01 ES015739-02, R01 ES015739] Funding Source: Medline
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Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
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