Journal
JOURNAL OF MASS SPECTROMETRY
Volume 47, Issue 12, Pages 1571-1575Publisher
WILEY-BLACKWELL
DOI: 10.1002/jms.3118
Keywords
secondary electrospray ionization; ion funnel; breath analysis; online mass; spectrometry; FTICR
Funding
- Sino Swiss Science and Technology Cooperation Program [IZLCZ2 123987]
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In this study, we used secondary electrospray ionization mass spectrometry assisted by an ion funnel (IF) operating at ambient pressure to find compounds in the mass range of 100500 m/z in online breath fingerprinting experiments. In low-resolution experiments conducted on an ion trap instrument, we found that pyridine is present in breath of individuals long after drinking coffee. In high-resolution experiments conducted on a Fourier transform ion cyclotron resonance, we found more than 30 compounds in the mass range of 100500 m/z in analogous online breath experiments. More than a third of these compounds have molecular weights above 200 Daltons and have not been mentioned in previous studies. In low-resolution experiments as well as experiments without the IF, these compounds could not be detected. Copyright (c) 2012 John Wiley & Sons, Ltd.
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