High spatial resolution imaging mass spectrometry and classical histology on a single tissue section

The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 mu m for sagittal sections of the cerebellum from rat brain. Copyright (C) 2011 John Wiley & Sons, Ltd.