Journal
JOURNAL OF MASS SPECTROMETRY
Volume 46, Issue 8, Pages 794-803Publisher
WILEY
DOI: 10.1002/jms.1944
Keywords
ND; EESI; viscous samples; cosmetic products; hormones; sulfonamides; quantitative detection; high throughput analysis
Funding
- Innovation Method Fund of China [2008IM40400]
- MOST of China [2009DFA30800]
- Innovation Method Fund of China [2008IM40400]
- MOST of China [2009DFA30800]
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A sensitive method based on a geometry-independent neutral desorption (GIND) in combination with extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection of illicit additives such as sulfonamides and hormones in highly viscous cosmetic products. The method gave a low limit of detection (LOD) (in the range of 0.001-1 ng/g), acceptable relative standard deviation (RSD = 6.8-11.4%) and reasonable recovery (87-116%) for direct measuring of nine types of hormones and sulfonamides in the cosmetic products. The average measurement time for two types of samples was less than 1 min. Trace amounts of analytes in commercial cosmetic products have been quantitatively detected, without any sample pretreatment. The experimental results showed that non-volatile illicit additives such as sulfonamides and hormones could be sensitively liberated using the GIND device for quantitative detection from the highly viscous cosmetic products, demonstrating that GIND-EESI-MS is a promising tool for high throughput, sensitive and quantitative analysis of highly complex viscous samples. Copyright (C) 2011 John Wiley & Sons, Ltd.
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