Journal
JOURNAL OF MASS SPECTROMETRY
Volume 46, Issue 10, Pages 1046-1050Publisher
WILEY-BLACKWELL
DOI: 10.1002/jms.1986
Keywords
imaging; mass spectrometry; lipids; chemical ink jet printer
Funding
- National Institute on Drug Abuse, NIH
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Imaging mass spectrometry using matrix-assisted laser desorption/ionization allows the detailed mapping of biomolecules directly from tissue. Matrix deposition is the key step for successful imaging. The appropriate concentration and deposition of matrix is critical for extraction, desorption, and ionization of molecules from tissue without losing molecular localization. The main challenge to meet these criteria is to deposit matrix droplets homogeneously on the tissue section. This work shows how a chemical inkjet printer was used for this purpose resulting in the imaging of phosphatidylcholines and sulfatides. The intricacies involved in effective matrix deposition are discussed. Copyright (C) 2011 John Wiley & Sons, Ltd.
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