Journal
JOURNAL OF MASS SPECTROMETRY
Volume 46, Issue 4, Pages 383-390Publisher
WILEY-BLACKWELL
DOI: 10.1002/jms.1904
Keywords
pharmaceuticals; cytostatic agents; mass spectrometry; LC-MS/MS; APPI; APCI; ESI
Funding
- Consejo Nacional de Ciencia y Tecnologia de Mexico (CONACYT)
- Canadian Foundation for Innovation (equipment)
- Natural Sciences and Engineering Research Council of Canada
- St. Lawrence Action Plan
Ask authors/readers for more resources
The applicability of three different ionization techniques: atmospheric pressure photoionization (APPI), atmospheric pressure chemicalionization(APCI) and electrospray ionization(ESI) was tested for the liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of five target pharmaceuticals (cyclophosphamide, methotrexate, bezafibrate, enalapril and orlistat) in wastewater samples. Performance was compared both by flow injection analysis (FIA) and on-column analysis in deionized water and wastewater samples. A column switching technique for the on-line extraction and analysis of water samples was used. For both FIA and on-column analysis, signal intensity and signal-to-noise (S/N) ratio of the target analytes in the three sources were studied. Limits of detection and matrix effects during the analysis of wastewater samples were also investigated. ESI generated significantly larger peak areas and higher S/N ratios than APCI and APPI in FIA and in on-column analysis. ESI was proved to be the most suitable ionization method as it enabled the detection of the five target compounds, whereas APCI and APPI ionized only four compounds. Copyright (C) 2011 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available