Journal
JOURNAL OF MASS SPECTROMETRY
Volume 44, Issue 11, Pages 1604-1612Publisher
WILEY
DOI: 10.1002/jms.1674
Keywords
mass spectrometry; chemical warfare agents; N,N-dialkylaminoethane-2-thiols; ion-pairing liquid chromatography; ultra performance liquid chromatography
Funding
- Ministry of Education, Youth and Sports, Czech Republic [MSM6198959216]
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N,N-dialkylaminoethane-2-thiols belong to the group of precursors and degradation products of chemical warfare agents (CWAs). These compounds were analyzed by means of electrospray ionization-multiple stage mass spectrometry (ion trap) and proposed fragments were confirmed by accurate mass measurement using a QqTOF system. The fragmentation pathways of studied compounds and the products of oxidation (formation of -S-S- linkage) were described. Some minor interesting processes, such as rearrangement of SH group, were observed and proved. A new mu LC/MS method, based on ion-pairing chromatography, was developed. Trifluoroacetic acid was employed as an ion-pairing agent to increase the low retention of compounds of interest in the reverse-phase system. The technique was compared with the UPLC/MS method, allowing fast analysis of all the studied thiols as well as an explorative control of originated disulfides. Copyright (C) 2009 John Wiley & Sons, Ltd.
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