Journal
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Volume 16, Issue 3, Pages 247-256Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-011-9221-5
Keywords
Senescence; Oncogene-induced senescence; Breast cancer; Anticancer barrier; DDR
Categories
Funding
- USAMRMC [BC030755, BC073703]
- National Institutes of Health [CA124820]
- Robert and Janice McNair Foundation
- CDMRP [BC083190]
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While senescence has been known for some time as an inevitable result of repeated DNA replication, oncogene-induced senescence (OIS) represents a relatively new phenomenon. OIS, like apoptosis, has emerged to represent a putative barrier to tumorigenesis in many tissues, including the breast. Here we discuss signals that initiate OIS, evidence for its role in tumor suppression, and mechanisms for its evasion in tumorigenesis.
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