Journal
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Volume 13, Issue 4, Pages 407-413Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-008-9097-1
Keywords
IGF-IR; Mammary development; Mammary tumorigenesis; Epithelial to mesenchymal transition; Pregnancy
Categories
Ask authors/readers for more resources
Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been available for about the same period of time, it is surprising that transgenic mice overexpressing the IGF-IR in the mammary gland have only recently been characterized. This review will describe the effects of IGF-IR overexpression on mammary ductal morphogenesis and mammary tumorigenesis in the two available transgenic models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available