Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 322, Issue 6, Pages 609-613Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2009.10.024
Keywords
Brownian motion; Magnetization harmonics; Magnetic Particle Imaging; Functional biosensing; Superparamagnetic nanoparticles
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Dynamic magnetization of nanoparticles is a promising means of functional biosensing. We demonstrate a method for rapid monitoring of relative changes in the viscous environment of superparamagnetic nanoparticles using a ratio of magnetization harmonics. Initial results are capable of detecting changes in viscosity on the order of 0.05 cP. This technique should allow for real-time monitoring of many of the dynamic magnetization applications which have been proposed using AC susceptibility. Further, incorporation of this technique into a harmonic-based imaging system like magnetic particle imaging would allow for in vivo functional imaging capabilities. (C) 2009 Elsevier B. V. All rights reserved.
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