Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 321, Issue 10, Pages 1539-1547Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2009.02.082
Keywords
Magnetic nanoparticles; Maghemite; MRI; Stem cells; Biocompatibility; Contrast agent
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Maghemite nanoparticles with various coatings were prepared by the coprecipitation method and characterized by transmission electron microscopy, dynamic light scattering and IR in terms of morphology, size, polydispersity and surface coating. The labeling efficiency and the viability of both rat and human mesenchymal stem cells labeled with Endorem (R), poly(L-lysine) (PLL)-modified Endorem (R), uncoated gamma-Fe2O3, D-mannose-, PLL- or poly(N,N-dimethylacrylamide) (PDMAAm)-coated gamma-Fe2O3 nanoparticles were compared. Coated gamma-Fe2O3 nanoparticles labeled cells better than did Endorem (R). High relaxation rates and in vitro magnetic resonance imaging of cells labeled with coated nanoparticles showed clearly visible contrast compared with unlabeled cells or cells labeled with Endorem (R). (c) 2009 Elsevier B.V. All rights reserved.
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