Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 321, Issue 18, Pages 2799-2804Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2009.04.020
Keywords
Targeted drug delivery; PH-responsive; Hybrid nanoparticle; Magnetite; Atom transfer radical polymerization
Funding
- National Natural Science Foundation of China [20574042, 20836004, 50573040]
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The synthesis of magnetite nanoparticles coated with pH-sensitive poly((2-dimethylamino) ethyl methacrylate)(PDMAEMA) via atom transfer radical polymerization(ATRP) for use as novel potential carriers for targeted drug delivery and controllable release is reported. The organic/inorganic hybrid nanoparticles were obtained with an arrow molecular weight distribution. The pH-sensitivity of the nanoparticles was investigated by the measurement of the pH dependence of hydrodynamic radius and the superparamagnetism was illustrated by vibrating sample magnetometer(VSM). The behavior of model drug phenolphthalein released from the nanoparticles indicated that the rate of drug release could be effectively controlled by altering the pH values of the environment. (C) 2009 Elsevier B. V. All rights reserved.
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