Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 321, Issue 10, Pages 1575-1579Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2009.02.090
Keywords
Ferrocarbon adsorbent; Magnetically guided transport of drug; Cytostatic; Oncology; Animal test; Biodistribution of doxorubicin; Phagocytosis by macrophages; Transport to lymph node
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Biodistribution of doxorubicin and ferrocarbon carrier particles in organism during and after magnetically controlled anti-tumor drug delivery and deposition was studied. Animal tests show high concentration of the cytostatic drug in the target zone, while its concentration is three orders of magnitude lower in bloodstream and other organs. A significant depot of the drug remains on the deposited particles days after the procedure. Macrophages actively phagocytose the ferrocarbon (FeC) particles and remain viable long enough to carry them to the lymph nodes. (C) 2009 Elsevier B.V. All rights reserved.
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