Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 320, Issue 21, Pages 2688-2691Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2008.05.048
Keywords
magnetic nanoparticles; bio-vector; stem cell
Funding
- Ministry of Education, Science & Technology (MoST), Republic of Korea [K08006] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated. (C) 2008 Published by Elsevier B.V.
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