Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 41, Issue 6, Pages 1615-1621Publisher
WILEY
DOI: 10.1002/jmri.24719
Keywords
corticomedullary differentiation; kidney; magnetic resonance imaging; cortical thickness; steady-state free precession (SSFP)
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PurposeTo assess whether noncontrast-enhanced steady-state free precession (SSFP) magnetic resonance imaging (MRI) with a spatially selective inversion recovery (IR) pulse can improve the visibility of renal corticomedullary differentiation in patients showing renal dysfunction, and to investigate the correlation between renal cortical thickness and estimated glomerular filtration rate (eGFR). Materials and MethodsSixty-five patients with and without chronic kidney diseases (CKD) were investigated. Based on eGFR, patients were divided into three groups (Group 1, eGFR<60; Group 2, eGFR=60-90; and Group 3, eGFR>90). All patients underwent noncontrast-enhanced SSFP MRI with spatially selective IR pulses and minimal renal cortical thickness was measured. ResultsThe mean corticomedullary contrast ratio was significantly higher in SSFP images with optimal TI than in in-phase images in all three groups (P=0.001). Positive correlation was seen between the corticomedullary contrast ratio in SSFP images with optimal TI and eGFR (P=0.011, r=0.314). A significantly positive correlation was observed between minimal renal cortical thickness and eGFR (P<0.01, r=0.495). ConclusionNoncontrast-enhanced SSFP MRI with a spatially selective IR pulse using optimal TI can improve the visibility of renal corticomedullary differentiation even in patients with renal insufficiency. The decrease in renal cortical thickness measured using this technique correlated significantly with eGFR. J. Magn. Reson. Imaging 2015;41:1615-1621. (c) 2014 Wiley Periodicals, Inc.
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