Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 38, Issue 6, Pages 1578-1584Publisher
WILEY-BLACKWELL
DOI: 10.1002/jmri.24071
Keywords
bone marrow; water-fat imaging; Dixon MRI
Funding
- National Institutes of Health [1R03AR055333, 1K12-HD055887, 1R01CA154491]
- PHS Cancer Center [P30 CA77598]
- Biotechnology Research Center (BTRC) [P41 RR008079, P41 EB015894]
- Clinical and Translational Science Institute (CTSI) of University of Minnesota [NIH 8UL1TR0001114]
- Minnesota Medical Foundation (MMF)
- BIRCWH (Building Interdisciplinary Careers in Women's Health) program
Ask authors/readers for more resources
PurposeTo assess the feasibility of using fat-fraction imaging for measuring marrow composition changes over large regions in patients undergoing cancer therapy. Materials and MethodsThirteen women with gynecologic malignancies who were to receive radiation and/or chemotherapy were recruited for this study. Subjects were imaged on a 3T magnetic resonance (MR) scanner at baseline (after surgery but before radiation or chemotherapy), 6 months, and 12 months after treatment. Water-fat imaging was used to generate high-resolution, 3D signal fat fraction (sFF) maps extending from mid-femur to L3. Treatment changes were assessed by measuring marrow sFF in the L4 vertebra, femoral necks, and control tissues. ResultsPretreatment and 6-month scans were compared in nine women. sFF increased significantly in both the L4 vertebral marrow (P = 0.04) and the femoral necks (P = 0.03), while no significant change was observed in control regions. Qualitatively, chemotherapy changes were more uniform in space, whereas the radiation-induced changes were largest in marrow regions inside and close to the target radiation field. ConclusionWater-fat MRI is sensitive to changes in red/yellow marrow composition, and can be used for quantitative and qualitative assessment of treatment-induced marrow damage. J. Magn. Reson. Imaging 2013;38:1578-1584. (c) 2013 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available