Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 38, Issue 5, Pages 1083-1093Publisher
WILEY
DOI: 10.1002/jmri.24069
Keywords
diabetes mellitus; peripheral neuropathy; intermuscular adipose tissue; muscle
Funding
- National Center for Medical Rehabilitation Research of the National Institute of Child Health and Human Development of the National Institutes of Health [R21 HD058938, T32 HD007434, K12 HD055931, R24HD050837]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 RR024992]
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PurposeTo describe a semi-automated program that will segment subcutaneous fat, muscle, and adipose tissue in the foot using MR imaging, determine the reliability of the program between and within raters, and determine the validity of the program using MR phantoms. Materials and MethodsMR images were acquired from 19 subjects with and without diabetes and peripheral neuropathy. Two raters segmented and measured volumes from single MR slices at the forefoot, midfoot, and hindfoot at two different times. Intra- and inter-rater correlation coefficients were determined. Muscle and fat MR phantoms of known volumes were measured by the program. ResultsMost ICC reliability values were over 0.950. Validity estimates comparing MR estimates and known volumes resulted in r(2) values above 0.970 for all phantoms. The root mean square error was less than 5% for all phantoms. ConclusionSubcutaneous fat, lean muscle, and adipose tissue volumes in the foot can be quantified in a reliable and valid way. This program can be applied in future studies investigating the relationship of these foot structures to functions in important pathologies, including the neuropathic foot or other musculoskeletal problems. J. Magn. Reson. Imaging 2013;38:1083-1093. (c) 2013 Wiley Periodicals, Inc.
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