Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 35, Issue 3, Pages 492-511Publisher
WILEY
DOI: 10.1002/jmri.22833
Keywords
magnetic resonance imaging; liver; biliary; hepatobiliary gadolinium based contrast agents; gadobenate dimeglumine; gadoxetic acid
Funding
- GE Healthcare
- National Institutes of Health (NIH) [RC1 EB010384]
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The advent of gadolinium-based hepatobiliary contrast agents offers new opportunities for diagnostic magnetic resonance imaging (MRI) and has triggered great interest for innovative imaging approaches to the liver and bile ducts. In this review article we discuss the imaging properties of the two gadolinium-based hepatobiliary contrast agents currently available in the U.S., gadobenate dimeglumine and gadoxetic acid, as well as important pharmacokinetic differences that affect their diagnostic performance. We review potential applications, protocol optimization strategies, as well as diagnostic pitfalls. A variety of illustrative case examples will be used to demonstrate the role of these agents in detection and characterization of liver lesions as well as for imaging the biliary system. Changes in MR protocols geared toward optimizing workflow and imaging quality are also discussed. It is our aim that the information provided in this article will facilitate the optimal utilization of these agents and will stimulate the reader's pursuit of new applications for future benefit. J. Magn. Reson. Imaging 2012;35:492-511. (c) 2011 Wiley Periodicals, Inc.
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