Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 34, Issue 3, Pages 623-633Publisher
WILEY-BLACKWELL
DOI: 10.1002/jmri.22637
Keywords
bone; solid state MRI; P-31 SMRI; UTE; osteoporosis; WASPI
Funding
- National Institute of Biomedical Imaging and Bioengineering [R01-EB004012]
- National Center for Research Resources [P41-RR14075]
- Peabody Foundation
- Athinoula A. Mar Linos Center for Biomedical Imaging
- Orthopedic Surgery Foundation of the Children's Hospital, Boston
- MIND Institute
Ask authors/readers for more resources
Purpose: To implement solid state P-31 MRI (P-31 SMRI) in a clinical scanner to visualize bone mineral. Materials and Methods: Wrists of seven healthy volunteers were scanned. A quadrature wrist P-31 transmit/receive coil provided strong B-1 and good signal-to-noise ratio (SNR). A H-1-P-31 frequency converter was constructed to enable detection of the P-31 signal by means of the H-1 channel. Data points lost in the receiver dead time were recovered by a second acquisition with longer dwell time and lower gradient strength. Results: Three-dimensional P-31 images, showing only bone mineral of the wrist, were obtained with a clinical 3 Tesla (T) scanner. In the best overall case an image with isotropic resolution of similar to 5.1 mm and SNR of 30 was obtained in 37 min. P-31 NMR properties (resonance line width 2 kHz and T-1 17-19 s) of in vivo human bone mineral were measured. Conclusion: In vivo P-31 SMRI visualization of human wrist bone mineral with a clinical MR scanner is feasible with suitable modifications to circumvent the scanners' limitations in reception of short-T-2 signals. Frequency conversion methodology is useful for implementing P-31 SMRI measurements on scanners which do not have multinuclear capability or for which the multinuclear receiver dead time is excessive.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available