Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 33, Issue 4, Pages 974-979Publisher
WILEY-BLACKWELL
DOI: 10.1002/jmri.22489
Keywords
bone marrow adiposity; MR spectroscopy; osteoporosis
Funding
- NIH/NCRR UCSF-CTSI [UL1 RR024131-01]
- NIH/NIAMS [RC1AR058405-01]
- Roche Inc.
- UCSF Research Evaluation and Allocation Committee (REAC)
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Purpose: To determine the reproducibility of proton MR spectroscopy ((1)H-MRS) for assessing vertebral bone marrow adiposity at 3 Tesla (T); to evaluate variation of marrow adiposity at different vertebral levels; and to demonstrate the feasibility of using (1)H-MRS at 3T for evaluating marrow adiposity in subjects with low bone density. Materials and Methods: Single voxel MRS was acquired at vertebral body L1 to L4 at 3T in 51 postmenopausal females including healthy controls (n = 13) and patients with osteoporosis/osteopenia (n = 38). Marrow fat contents were compared between vertebral levels and between groups using analysis of variance (ANOVA). Six subjects were scanned twice to evaluate technique reproducibility. Results: The average coefficient of variation of vertebral marrow fat content quantification was 1.7%. Marrow fat content significantly increased from L1 to L4. The average fat content was significantly elevated in patients with osteoporosis/osteopenia compared with controls, adjusted for age and body mass index (P < 0.05). Conclusion: In vivo MRS at high field strength provides reliable measurement of marrow adiposity with excellent reproducibility and can be a valuable tool for providing complementary information on bone quality and potentially also fracture risk.
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