Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 31, Issue 5, Pages 1067-1074Publisher
WILEY
DOI: 10.1002/jmri.22161
Keywords
depression severity; fMRI; estimation model; fuzzy logic; Hamilton Depression Rating Scales (HAMD)
Funding
- National High-tech Research and Development Program of China [2008AA02Z410]
- National Natural Science Foundation of China [30900356]
- Research Fund for the Doctoral Program of Higher Education of China [200802861079]
- Key Laboratory of Child Development and Learning Science, Ministry of Education, China [CDLS-2009-07]
- National 973 Program of China [2007CD512303]
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Purpose: To develop a functional MRI (fMRI) signal based model that can evaluate depression severity in a numeric form; therefore, depressed patients can be identified during the course of illness, independent from symptoms. Materials and Methods: Data from 20 medication-free depressed patients and 16 healthy subjects were analyzed. The event-related fMRI scanning features under sad facial emotional stimuli were extracted as model inputs. Fuzzy logic and a genetic algorithm were used to provide suitable model outputs for numeric estimations of depression. Results: The correlation value r between the model estimations and the professional Hamilton Depression Rating Scales (HAMD) was 0.7886 with P < 0.00016. A typical tracking history for a particular subject has also promised the possibility for early disease warning, when the clinal symptoms are ambiguous or recessive. Conclusion: A numeric and objective estimation for the course of illness can be provided. The model can be used by psychiatrists to track the recovery process. As a simple extended application, the proposed model can be applied to classify subjects into different patterns: major depression, moderate depression, or healthy.
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