Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 32, Issue 2, Pages 320-325Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.22233
Keywords
MRS; lactate; hypoxia; hyperoxia; MEGA-PRESS
Funding
- Research Councils UK
- UK Medical Research Council
- Natural Sciences and Engineering Research Council of Canada
- Medical Research Council [G120/969] Funding Source: researchfish
- MRC [G120/969] Funding Source: UKRI
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Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O(2)). hypoxic (12% O(2)), and hyperoxic (40% O(2)) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.
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