Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 30, Issue 1, Pages 145-152Publisher
WILEY
DOI: 10.1002/jmri.21809
Keywords
liver fat quantification; magnetic resonance spectroscopy; PRESS; STEAM
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [1U01DK061734, 5U01DK061730, R01 DK71486]
- National Institute of Child Health and Human Development (NICHD)
- National Center of Minority Health and Health Disparities [P60 MD00220]
- National Center for Research Resources for the General Clinical Research Center at UCSD [M01 RR000827]
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Purpose: To compare PRESS and STEAM MR spectroscopy for assessment of liver fat in human subjects. Materials and Methods: Single-voxel (20 x 20 x 20 mm) PRESS and STEAM spectra were obtained at 1.5T in 49 human subjects with known or suspected fatty liver disease. PRESS and STEAM sequences were obtained with fixed TR (1500 msec) and different TE (five PRESS spectra between TE 30-70 msec, five STEAM spectra between TE 20-60 msec). Spectra were quantified and T2 and T2-corrected peak area were calculated by different techniques. The values were compared for PRESS and STEAM. Results: Water T2 values from PRESS and STEAM were not significantly different (P = 0.33). Fat peak T2s were 25%-50% shorter on PRESS than on STEAM (P < 0.02 for all comparisons) and there was no correlation between T2s of individual peaks. PRESS systematically overestimated the relative fat peak areas (by 7%-263%) compared to STEAM (P < 0.005 for all comparisons). The peak area given by PRESS was more dependent on the T2-correction technique than STEAM. Conclusion: Measured liver fat depends on the MRS sequence used. Compared to STEAM, PRESS underestimates T2 values of fat, overestimates fat fraction, and provides a less consistent fat fraction estimate, probably due to J coupling effects.
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