Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 30, Issue 1, Pages 185-193Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.21820
Keywords
magnetic resonance imaging; whole-body; water-fat imaging; visceral adipose tissue; subcutaneous adipose tissue; automated segmentation
Funding
- Swedish Research Council [K2006-71X-06676-24-3]
- Philips Healthcare
- AstraZeneca
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Purpose: To present an automated algorithm for segmentation of visceral, subcutaneous, and total volumes of adipose tissue depots (VAT, SAT, TAT) from whole-body MRI data sets and to investigate the VAT segmentation accuracy and the reproducibility of all depot assessments. Materials and Methods: Repeated measurements were performed on 24 volunteer subjects using a 1.5 Testa clinical MRI scanner and a three-dimensional (3D) multi-gradient-echo sequence (resolution: 2.1 x 2.1 x 8 mm(3), acquisition time: 5 min 15 s). Fat and water images were reconstructed. and fully automated segmentation was performed. Manual segmentation of the VAT reference was performed by an experienced operator. Results: Strong correlation (R = 0.999) was found between the automated and manual VAT assessments. The automated results underestimated VAT with 4.7 +/- 4.4%. The accuracy was 88 +/- 4.5% and 7.6 +/- 5.7% for true positive and false positive fractions, respectively. Coefficients of variation front the repeated measurements were: 2.32% +/- 2.61%, 2.25% +/- 2.10%, and 1.01% +/- 0.74% for VAT, SAT, and TAT, respectively. Conclusion: Automated and manual VAT results correlated strongly. The assessments of all depots were highly reproducible. The acquisition and postprocessing techniques presented are likely useful in obesity related studies.
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