Comparison of different contrast agents and doses for quantitative MR myocardial perfusion imaging

Purpose: To investigate three different contrast agents at different injection volumes for repetitive quantitative multislice myocardial perfusion imaging using the prebolus technique. Materials and Methods: Two consecutive prebolus perfusion measurements were performed on a 1.5T scanner using identical injection volumes for the first and second examination to test the reproducibility for possible rest and stress examination in normal volunteers. Either 1-8 mL, 1-12 mL Gd-DTPA, 1-4 mL, 1-6 mL. 1-9 mL Gd-BOPTA, or 1-4 mL. 1-6 mL gadobutrol were applied. Results: In cases where injection volumes were sufficiently small, there was no indication of significant differences in quantitative perfusion values with respect to the different contrast agents. Increasing the bolus volume improved the contrast-to-noise ratio (CNR) but led to saturation effects and underestimation of the true perfusion. The highest CNR was measured for gadobutrol (6 mL, p < 0.0005 compared to 8 mL Gd-DTPA). The smallest difference of perfusion values between the first and the second prebolus examination was found for Gd-BOPTA (p:5 0.006 compared Gd-DTPA). Conclusion: Prebolus examinations for quantitative myocardial perfusion imaging are possible with all three contrast agents for sufficient small injection volumes. GdBOPTA was found to be advantageous for a combined quantitative rest and stress examination.