Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 27, Issue 5, Pages 1175-1180Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.21337
Keywords
inversion recovery with ON-resonant water suppression (IRON); off-resonance imaging; monocrystalline iron oxide nanoparticle (MION-47); magnetic resonance lymphography
Funding
- NCI NIH HHS [R24 CA092782-05, P50 CA086355, R24 CA092782, P50CA86355, R24CA92782, P50 CA086355-01] Funding Source: Medline
- NHLBI NIH HHS [R01 HL073223-04, R01 HL084186, R01 HL073223] Funding Source: Medline
- NIBIB NIH HHS [1 K08 EB004922-01, K08 EB004922] Funding Source: Medline
Ask authors/readers for more resources
Purpose: To investigate the utility of inversion recovery with ON-resonant water suppression (IRON) to create positive signal in normal lymph nodes after injection of superparamagnetic nanoparticles. Materials and Methods: Experiments were conducted on six rabbits, which received a single bolus injection of 80 p,mol Fe/kg monocrystalline iron oxide nanoparticle (MION-47). Magnetic resonance imaging (MRI) was performed at baseline, I day, and 3 days after MION-47 injection using conventional T-1- and T-2*-weighted sequences and IRON. Contrast-to-noise ratios (CNR) were measured in blood and in paraaortic lymph nodes. Results: On T-2*-weighted images, as expected, signal attenuation was observed in areas of paraaortic lymph nodes after MION-47 injection. However, using IRON the paraaortic lymph nodes exhibited very high contrast enhancement, which remained 3 days after injection. CNR with IRON was 2.2 +/- 0.8 at baseline, increased markedly 1 day after injection (23.5 +/- 5.4, P < 0.01 vs. baseline), and remained high after 3 days (21.8 +/- 5.7, *P < 0.01 vs. baseline). CNR was also high in blood I day after injection (42.7 +/- 7.2 vs. 1.8 +/- 0.7 at baseline, P < 0.01) but approached baseline after 3 days (1.9 +/- 1.4, P = NS vs. baseline). Conclusion: IRON in conjunction with superparamagnetic nanoparticles can be used to perform 'positive contrast' MR-lymphography, particularly 3 days after injection of the contrast agent, when signal is no longer visible within blood vessels. The proposed method may have potential as an adjunct for nodal staging in cancer screening.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available