Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 241, Issue -, Pages 53-59Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2013.11.016
Keywords
NMR; Biological macromolecules; Proteins; Dynamics; Correlated dynamics; NOE; Nuclear Overhauser effect; eNOE; Structure calculation; Structure ensemble
Funding
- Swiss National Foundation
- Swiss National Science Foundation [140214]
- ETH Research Grant [ETH-04 13-1]
- Vetenskap Ladet (VR) post doc fellowship
- Lichtenberg program of the Volkswagen Foundation
- Grants-in-Aid for Scientific Research [25440032] Funding Source: KAKEN
Ask authors/readers for more resources
Confined by the Boltzmann distribution of the energies of the states, a multitude of structural states are inherent to biomolecules. For a detailed understanding of a protein's function, its entire structural landscape at atomic resolution and insight into the interconversion between all the structural states (i.e. dynamics) are required. Whereas dedicated trickery with NMR relaxation provides aspects of local dynamics, and 3D structure determination by NMR is well established, only recently have several attempts been made to formulate a more comprehensive description of the dynamics and the structural landscape of a protein. Here, a perspective is given on the use of exact NOEs (eNOEs) for the elucidation of structural ensembles of a protein describing the covered conformational space. (c) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available