4.3 Article

Sampling scheme and compressed sensing applied to solid-state NMR spectroscopy

Journal

JOURNAL OF MAGNETIC RESONANCE
Volume 237, Issue -, Pages 40-48

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2013.09.013

Keywords

Non-uniform sampling; Solid-state NMR; Sensitivity; Protein NMR; Compressed sensing; Oriented samples; Membrane proteins

Funding

  1. National Institutes of Health [RO1GM066978, RO1GM099986, EB005161, AI074805]
  2. [P41EB002031]

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We describe the incorporation of non-uniform sampling (NUS) compressed sensing (CS) into oriented sample (OS) solid-state NMR for stationary aligned samples and magic angle spinning (MAS) Solid-state NMR for unoriented 'powder' samples. Both simulated and experimental results indicate that 25-33% of a full linearly sampled data set is required to reconstruct two- and three-dimensional solid-state NMR spectra with high fidelity. A modest increase in signal-to-noise ratio accompanies the reconstruction. (C) 2013 Elsevier Inc. All rights reserved.

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