Acceleration of multi-dimensional propagator measurements with compressed sensing

NMR can probe the microstructures of anisotropic materials such as liquid crystals, stretched polymers and biological tissues through measurement of the diffusion propagator, where internal structures are indicated by restricted diffusion. Multi-dimensional measurements can probe the microscopic anisotropy, but full sampling can then quickly become prohibitively time consuming. However, for incompletely sampled data, compressed sensing is an effective reconstruction technique to enable accelerated acquisition. We demonstrate that with a compressed sensing scheme, one can greatly reduce the sampling and the experimental time with minimal effect on the reconstruction of the diffusion propagator with an example of anisotropic diffusion. We compare full sampling down to 64x sub-sampling for the 2D propagator measurement and reduce the acquisition time for the 3D experiment by a factor of 32 from similar to 80 days to similar to 2.5 days. (C) 2011 Elsevier Inc. All rights reserved.