Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 209, Issue 2, Pages 332-336Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2011.01.010
Keywords
Hyperpolarized C-13; Dynamic metabolic imaging; Pyruvate; Spiral CSI
Funding
- NCRR NIH HHS [P41 RR009784-05, P41 RR009784] Funding Source: Medline
- NIAAA NIH HHS [R01 AA005965, R01 AA005965-10, R01 AA018681, R37 AA005965, U01 AA013521-05, R01 AA018681-01, U01 AA013521] Funding Source: Medline
- NIBIB NIH HHS [R01 EB009070-01A1, R01 EB009070] Funding Source: Medline
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Undersampled spiral CSI (spCSI) using a free induction decay (FID) acquisition allows sub-second metabolic imaging of hyperpolarized C-13. Phase correction of the FID acquisition can be difficult, especially with contributions from aliased out-of-phase peaks. This work extends the spCSI sequence by incorporating double spin echo radiofrequency (RF) pulses to eliminate the need for phase correction and obtain high quality spectra in magnitude mode. The sequence also provides an added benefit of attenuating signal from flowing spins, which can otherwise contaminate signal in the organ of interest. The refocusing pulses can potentially lead to a loss of hyperpolarized magnetization in dynamic imaging due to flow of spins through the fringe field of the RF coil, where the refocusing pulses fail to provide complete refocusing. Care must be taken for dynamic imaging to ensure that the spins remain within the B-1-homogeneous sensitive volume of the RF coil. (C) 2011 Elsevier Inc. All rights reserved.
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