Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 207, Issue 2, Pages 352-355Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2010.09.010
Keywords
Spectroscopy; Carbon-13 MRS; Brain; Bicarbonate; Glial metabolism
Funding
- NIH [K25DA21112]
- Rudi Schulte Research Institute of Santa Barbara, CA
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We demonstrate a robust procedure for the quantitative characterization of glial metabolism in human brain. In the past, the slope of the uptake and production of enriched label at steady state were used to determine metabolic rates, requiring the patient to be in the magnet for 120-160 min. In the present method, C-13 cerebral metabolite profiles were acquired at steady state alone on a routine clinical MR scanner in 25.6 min. Results obtained from the new short method (SAGA) were comparable to those achieved in a conventional, long method and effective for determination of glial metabolic rate in posterior-parietal and frontal brain regions. (C) 2010 Elsevier Inc. All rights reserved.
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