Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 206, Issue 2, Pages 190-199Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2010.07.004
Keywords
DCE-MRI; Water exchange; Shutter-speed; Pharmacokinetics; Patlak Plot
Funding
- NIH [RO1-NS40801, RO1-EB00422, RO1-EB007258, RO1-NS33618, RO1-NS34608 R21-CA114279]
- NMSS [RG 3168-A-1]
- W. M. Keck Foundation
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The accurate mapping of the tumor blood volume (TBV) fraction (v(b)) is a highly desired imaging biometric goal. It is commonly thought that achieving this is difficult, if not impossible, when small molecule contrast reagents (CRs) are used for the T-1-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This is because angiogenic malignant tumor vessels allow facile CR extravasation. Here, a three-site equilibrium water exchange model is applied to DCE-MRI data from the cerebrally-implanted rat brain U87 glioma, a tumor exhibiting rapid CR extravasation. Analyses of segments of the (and the entire) DCE data time-course with this shutter-speed pharmacokinetic model, which admits finite water exchange kinetics, allow TBV estimation from the first-pass segment. Pairwise parameter determinances were tested with grid searches of 2D parametric error surfaces. Tumor blood volume (v(b)), as well as v(e) (the extracellular, extravascular space volume fraction), and K-trans (a CR extravasation rate measure) parametric maps are presented. The role of the Patlak Plot in DCE-MRI is also considered. (C) 2010 Elsevier Inc. All rights reserved.
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