Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 192, Issue 2, Pages 258-264Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2008.03.003
Keywords
DNP; compressed sensing; sparse; MRSI; hyperpolarization
Funding
- NCI NIH HHS [R01 CA111291, R01-CA111291, R01 CA111291-02] Funding Source: Medline
- NIBIB NIH HHS [R01 EB007588-02, R21 EB005363, R01 EB007588-01, R01 EB007588] Funding Source: Medline
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High polarization of nuclear spins in liquid state through dynamic nuclear polarization has enabled the direct monitoring of C-13 metabolites in vivo at very high signal-to-noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes high-resolution 13C 3D-MRSI feasible. However, the number of phase encodes that can be fit into the short acquisition time for hyperpolarized imaging limits spatial coverage and resolution. To take advantage of the high SNR available from hyperpolarization, we have applied compressed sensing to achieve a factor of 2 enhancement in spatial resolution without increasing acquisition time or decreasing coverage. In this paper, the design and testing of compressed sensing suited for a flyback 13C 3D-MRSI sequence are presented. The key to this design was the undersampling of spectral k-space using a novel blipped scheme, thus taking advantage of the considerable sparsity in typical hyperpolarized C-13 spectra. Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility. (c) 2008 Elsevier Inc. All rights reserved.
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