Journal
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
Volume 50, Issue 6, Pages 644-652Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10601325.2013.784569
Keywords
Biomimetic; core cross-linked nanocarriers; controlled release; drug delivery
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Funding
- Qianjiang Talents Project of Zhejiang Province [2010R10023]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, the State Education Ministry [1001603-C]
- Natural Science Foundation of Zhejiang Province [Y4100045]
- Training Foundation for the Excellent Young Talents by the Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education [2011QN04]
- National Natural Science Foundation of China [51133006]
- Innovative Program for Graduate Students of Zhejiang Sci-Tech University [YCX12011]
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Biomimetic core cross-linked nanocarriers (CCL-NCs) with zwitterionic shell was constructed from an amphiphilic block copolymer poly(2-(dimethylamino) ethyl methacrylate-co-carboxybetaine)-b-polystyrene ((PDMAEMA-co-PCB)-b-PS) via mini-emulsion RAFT polymerization. CCL-NCs present in this report possess properties of redox-sensitivity, limited unspecific protein adsorptions and low cytotoxicity, which highly enhance their potential application in drug delivery. Morphology of CCL-NCs was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. The control release process has also been investigated under three different conditions with or without dithiothreitol (DTT) at pH 5.4, 6.5 and 7.4.
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