Journal
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
Volume 47, Issue 5, Pages 429-434Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10601321003659630
Keywords
Chitosan; scaffolds; lyophilization; sc.CO2; tissue engineering
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Funding
- Commonwealth Scholarship Commission-London
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Porous chitosan scaffolds with possible tissue engineering applications were synthesized by using lyophilization and supercritical carbon dioxide (sc.CO2) drying technique. 1% Chitosan (CS) solution in aq. acetic acid was treated with 37% formaldehyde solution; the resulting hydrogels were subjected to solvent-exchange prior to the final treatment procedures. Their morphology, pore structure, and physical properties were characterized by Fourier transform infrared spectroscopy (FTIR), thermal analysis, scanning electron microscopy (SEM), transmission electronmicroscopy (TEM) and the specific surface areas and porosities of scaffolds were determined by using N-2 adsorption. The sc.CO2 treated scaffolds showed a much greater surface area in comparison to the lyophilized one. Hence, sc.CO2 treated scaffolds is better for cell proliferation. We further investigated the bioactivity of sc.CO2 treated scaffolds using simulated body fluid (SBF). The sc.CO2 assisted chitosan scaffold prepared by using green chemistry approach is highly pure and from a hygienic point of view, it is an ideal material for tissue engineering applications.
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