Journal
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
Volume 46, Issue 10, Pages 943-948Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10601320903158263
Keywords
Superparamagnetic nanogels; enzymic resolution; immobilized -chymotrypsinc; (DL)-Phenylalanine; ionic liquid
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Funding
- National Natural Science Foundation of China [20504010]
- Chinese Ministry of Science and Technology [2009CB930000, 2009CB930300]
- Shanghai Municipality Commission [0752nm022, 0852nm03700, 0952nm05300]
- Shanghai Municipality Commission for International Corporation [09540709000]
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-Chymotrypsin immobilized on super paramagnetic nanogels covered with carboxyl groups, exhibited high stereoselectivity in kinetic resolution of racemic phenylalanine in toluene/water biphasic system, and even improved reusability over its parent free enzyme. The results also showed that the addition of ionic liquid to water phase could enhance the stereoselectivity of the immobilized enzyme to a certain extent while the conversion yield decreased. The long-term stability allows the supported enzyme with nano-scaled dimension to use in continuous chiral resolution reaction, which opens a new horizon for enzymatic chiral resolution in large-scale production.
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