Journal
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
Volume 45, Issue 11, Pages 931-937Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10601320802380158
Keywords
encapsulation; self-assembly; amphiphilic polymer; nano-particles; drug delivery; chemo-enzymatic; Novozyme-435; Candida antarctica lipase B; static light scattering; micelles
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Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.
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