Journal
JOURNAL OF LUMINESCENCE
Volume 130, Issue 2, Pages 270-279Publisher
ELSEVIER
DOI: 10.1016/j.jlumin.2009.09.002
Keywords
BSA; HSA; Hesperidin; Naringin; Interaction
Categories
Funding
- The Educational Office of Jilin Province [2007170]
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The interaction between flavonoids and proteins was investigated by fluorescence and absorption spectroscopy. The binding parameters of drugs with proteins were obtained according to the corrected fluorescence data by an improved calculation method. The Delta H, Delta S and Delta G obtained indicate that the van der Waals or hydrogen bond, electrostatic force and hydrophobic forces all play a role in the interaction of drugs with proteins. Based on Forster's theory, the binding average distance r between the protein and drug was evaluated and found to be less than 3 nm. The interaction of drug-metal ion complexes and proteins was also investigated. (C) 2009 Elsevier B.V. All rights reserved.
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