Journal
JOURNAL OF LOWER GENITAL TRACT DISEASE
Volume 18, Issue 2, Pages E43-E45Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/LGT.0b013e3182976219
Keywords
neovagina; squamous cell carcinoma; carcinoma; transsexual
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Background Carcinoma of the neovagina is extremely rare, and only one other case has been reported after sex-reassignment surgery. Malignancies seem to be dependent on the original tissue and are thought to be associated with HPV infection or chronic irritation. Case Report A 53-year-old male-to-female transsexual presented 21 years after initial surgery with vaginal discharge that was found to be due to a moderately differentiated squamous cell carcinoma. She was treated with chemoradiation with disease remission; however, she had significant stenosis and narrowing of the neovagina. Comment The optimum treatment is unclear, although radiation seems to be the most common technique with surgery an alternative. All patients should have regular clinical follow-up provided by a primary treating unit, which includes pelvic examination and cytologic smears. As a minimum, follow-up should occur as per other vaginal malignancies for at least 10 years.
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