Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 31, Issue 10, Pages 1448-1457Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10826070802039424
Keywords
ionic liquid; additive; base; amino acid; high-performance liquid chromatography
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In this paper, four bases, including cytosine, thymine, adenine, 6-chlorouracil and four amino acids, including L-histidine, L-tyrosine, L-phenylalanine, and DL-tryptophane, were separated with different types of ionic liquids as additives for the mobile phase in high-performance liquid chromatography. Four different ILs, including 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium tetrafluoroborate, 1-hexyl-3-methylimidazolium tetrafluoroborate, and 1-butyl-3-methylimidazolium chloride were used. The effects of the length of the alkyl group on the imidazolium ring and its counterion, the concentrations of the ionic liquids on the retention factor of the bases and amino acids are investigated. The results showed that the retention and resolution of the bases and amino acids were improved when ionic liquids were used as additives. The mechanism at the separation with ionic liquids as additive to mobile phase is discussed.
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