Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 31, Issue 15, Pages 2296-2304Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10826070802281653
Keywords
asymmetric hydrogenation; catalyst screening; chromatography; high throughput; HPLC; microfluidic; multiparallel; normal phase
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Rapid chiral method development using microfluidic multiparallel HPLC is illustrated with several examples of 'real world' pharmaceutical intermediates for which speed was critical for successful process development. It is shown that this rapid chiral method development approach is suitable for support of high throughput screening of enantioselective catalytic hydrogenation reactions and other high throughput experimentation initiatives in pharmaceutical process research.
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