Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 31, Issue 5, Pages 667-674Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10826070701853784
Keywords
pravastatin; serum levels; dyslipidemic patients
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A high performance liquid chromatography (HPLC) method for the estimation of pravastatin in human serum samples has been developed to monitor dyslipidemic patients. The method was fully validated and validation parameters were in the linearity range 10-200ng/mL, correlation coefficient 0.99, mean recovery 0.73, quantification limit 10ng/mL, and limit of detection, 5ng/mL; this method was applied for pravastatin determination in human serum from Mexican dyslipidemic patients. Pravastatin values found for three studied patients were 73, 57, and 10ng/mL, indicating the importance of monitoring, due to the metabolic variability of these chronic patients.
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