Journal
JOURNAL OF LIPOSOME RESEARCH
Volume 25, Issue 2, Pages 89-100Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08982104.2014.928890
Keywords
Bone metastasis; dual-modality imaging; iron oxide nanoparticles; liposome; quantum dots; RGD peptide
Funding
- National Natural Science Foundation of China [31171143]
- National Important Science Research Program of China [2011CB933503]
- National Key Technology Research and Development Program of China [2012BAI23B02]
- Natural Science Foundation of the Higher Education Institutions of Jiangsu Province [12KJD310004]
- Applied Basic Research Project Foundation of Nantong [BK2012064]
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We reported the development of multifunctional liposomes as a dual-modality probe to facilitate targeted magnetic resonance and fluorescent imaging of bone metastasis from advanced cancer. Multifunctional liposomes consisted of liposomes as a carrier, hydrophobic CdSe QDs in phospholipid bilayer, hydrophilic iron oxide nanoparticles in interior vesicle, lipid-PEG derivative on the surface and cRGDyk peptide conjugated to distal ends of lipid-PEG derivative. Excellent stability, effective detection signal, low toxicity, high resistance to phagocytosis by macrophages and good specificity to tumor of multifunctional liposomes were confirmed by in vitro characterization. The in vivo results demonstrated that multifunctional liposomes accumulated mainly in tumor and liver, indicating that targeted dual-modality imaging was achieved, and the results from two kinds of modalities were consistent and complementary. These findings provide a helpful strategy for detection of bone metastases in a more effective manner for initiation of appropriate therapy.
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