Journal
JOURNAL OF LIPID RESEARCH
Volume 55, Issue 5, Pages 799-807Publisher
ELSEVIER
DOI: 10.1194/jlr.R046094
Keywords
lysophospholipid acyltransferase; membrane biology; phospholipid metabolism
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
- National Center for Global Health and Medicine [24-001, 25-201]
- CREST, Japan Science and Technology Agency Grant
- Grants-in-Aid for Scientific Research [26870879] Funding Source: KAKEN
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Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 positions, respectively. The glycerophospholipid compositions of different cell types, organelles, and inner/outer plasma membrane leaflets are quite diverse. The acyl moieties of glycerophospholipids synthesized in the de novo pathway are subsequently remodeled by the action of phospholipases and lysophospholipid acyltransferases. This remodeling cycle contributes to the generation of membrane glycerophospholipid diversity and the production of lipid mediators such as fatty acid derivatives and lysophospholipids. Furthermore, specific glycerophospholipid transporters are also important to organize a unique glycerophospholipid composition in each organelle. Recent progress in this field contributes to understanding how and why membrane glycerophospholipid diversity is organized and maintained.
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