Related references
Note: Only part of the references are listed.Evolving concepts in cancer therapy through targeting sphingolipid metabolism
Jean-Philip Truman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)
Sphingosine Kinase 1 and Cancer: A Systematic Review and Meta-Analysis
Yun Zhang et al.
PLOS ONE (2014)
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors
K. Alexa Orr Gandy et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)
Structure guided design of a series of sphingosine kinase (SphK) inhibitors
Darin J. Gustin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism
Francesca Tonelli et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Synthesis of selective inhibitors of sphingosine kinase 1
Dong Jae Baek et al.
CHEMICAL COMMUNICATIONS (2013)
Roles, regulation and inhibitors of sphingosine kinase 2
Heidi A. Neubauer et al.
FEBS JOURNAL (2013)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Elucidations of the Catalytic Cycle of NADH-Cytochrome b5 Reductase by X-ray Crystallography: New Insights into Regulation of Efficient Electron Transfer
Mitsugu Yamada et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent
Kai Liu et al.
PLOS ONE (2013)
Fenretinide Causes Emphysema, Which Is Prevented by Sphingosine 1-Phoshate
Masanori Yasuo et al.
PLOS ONE (2013)
C22:0-and C24:0-dihydroceramides Confer Mixed Cytotoxicity in T-Cell Acute Lymphoblastic Leukemia Cell Lines
Michael W. Holliday et al.
PLOS ONE (2013)
Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis
Zhulun Wang et al.
STRUCTURE (2013)
In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase
Haydar Celik et al.
TOXICOLOGY (2013)
Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells
Hoe-Sup Byun et al.
MEDCHEMCOMM (2013)
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1
Mark E. Schnute et al.
BIOCHEMICAL JOURNAL (2012)
Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death
Aintzane Apraiz et al.
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE (2012)
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors
Mithun R. Raje et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival
Keng Gat Lim et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase
H. Zhang et al.
CELL PROLIFERATION (2012)
Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: Structure-activity relationships
Haydar Celik et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2012)
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy
Vincenzo Gagliostro et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b
Keng Gat Lima et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)
Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis
Benjamin T. Bikman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells
Stefka D. Spassieva et al.
JOURNAL OF LIPID RESEARCH (2012)
Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases
Peng Gao et al.
PLOS ONE (2012)
Dihydroceramide desaturase and dihydrosphingolipids: Debutant players in the sphingolipid arena
Gemma Fabrias et al.
PROGRESS IN LIPID RESEARCH (2012)
Regulation of Autophagy by Sphingolipids
Carmen Bedia et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2011)
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells
Aintzane Apraiz et al.
BMC CANCER (2011)
Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules
Susan Pyne et al.
CANCER RESEARCH (2011)
A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors
Mark A. Dickson et al.
CLINICAL CANCER RESEARCH (2011)
Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine
Carmen Bedia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide
Mehrdad Rahmaniyan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions
Mats H. M. Olsson et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)
Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration
Peng Gao et al.
MOLECULAR CANCER RESEARCH (2011)
Dihydroceramide desaturase activity is modulated by oxidative stress
Jolanta Idkowiak-Baldys et al.
BIOCHEMICAL JOURNAL (2010)
Development of a sphingosine kinase 1 specific small-molecule inhibitor
Jeremy A. Hengst et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
Francesca Tonelli et al.
CELLULAR SIGNALLING (2010)
Down- regulation of S1P1 Receptor Surface Expression by Protein Kinase C Inhibition
Sven-Christian Sensken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells
Zhehao Mao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells
Carolyn Loveridge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Sphingosine Kinase Mediates Resistance to the Synthetic Retinoid N-(4-Hydroxyphenyl)retinamide in Human Ovarian Cancer Cells
Giuditta Illuzzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids
Manuela Valsecchi et al.
JOURNAL OF LIPID RESEARCH (2010)
A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells
Vladimir Beljanski et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
In vitro anti-leukaemia activity of sphingosine kinase inhibitor
Clara Ricci et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells
Paola Signorelli et al.
CANCER LETTERS (2009)
Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts
Dmitri Kapitonov et al.
CANCER RESEARCH (2009)
Overexpression of Degenerative Spermatocyte Homolog 1 Up-Regulates the Expression of Cyclin D1 and Enhances Metastatic Efficiency in Esophageal Carcinoma Eca109 Cells
Wu Zhou et al.
MOLECULAR CARCINOGENESIS (2009)
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
Steven W. Paugh et al.
BLOOD (2008)
Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase
Jose M. Munoz-Olaya et al.
CHEMMEDCHEM (2008)
N-(4-hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell
Hongtao Wang et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells
Jacqueline M. Kraveka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
Wenjing Zheng et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
Masataka Kohno et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Novel procedure for modeling ligand/receptor induced fit effects
W Sherman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Use of an induced fit receptor structure in virtual screening
W Sherman et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2006)
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis
TA Taha et al.
FASEB JOURNAL (2005)
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
JR Van Brocklyn et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
TA Halgren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Structure of human erythrocyte NADH-cytochrome b5 reductase
S Bando et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase
G Triola et al.
JOURNAL OF ORGANIC CHEMISTRY (2003)
The biochemistry and medical significance of the flavonoids
BH Havsteen
PHARMACOLOGY & THERAPEUTICS (2002)
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
R Kolesnick
JOURNAL OF CLINICAL INVESTIGATION (2002)
The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent
MC Bewley et al.
BIOCHEMISTRY (2001)
Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
BJ Maurer et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
H Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)