Journal
JOURNAL OF LIPID RESEARCH
Volume 54, Issue 4, Pages 953-965Publisher
ELSEVIER
DOI: 10.1194/jlr.M032466
Keywords
lipids; hypertrophy; myocardial cardiomyopathy
Categories
Funding
- National Institutes of Health [1-RO1-DK-075017, DK-072488]
- American Heart Association [11GRNT7600027]
- Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center
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Presence of ectopic lipid droplets (LDs) in cardiac muscle is associated to lipotoxicity and tissue dysfunction. However, presence of LDs in heart is also observed in physiological conditions, such as when cellular energy needs and energy production from mitochondria fatty acid beta-oxidation are high (fasting). This suggests that development of tissue lipotoxicity and dysfunction is not simply due to the presence of LDs in cardiac muscle but due at least in part to alterations in LD function. To examine the function of cardiac LDs, we obtained transgenic mice with heart-specific perilipin 5 (Plin5) overexpression (MHC-Plin5), a member of the perilipin protein family. Hearts from MHC-Plin5 mice expressed at least 4-fold higher levels of plin5 and exhibited a 3.5-fold increase in triglyceride content versus nontransgenic littermates. Chronic cardiac excess of LDs was found to result in mild heart dysfunction with decreased expression of peroxisome proliferator-activated receptor (PPAR)alpha target genes, decreased mitochondria function, and left ventricular concentric hypertrophia. Lack of more severe heart function complications may have been prevented by a strong increased expression of oxidative-induced genes via NF-E2-related factor 2 antioxidative pathway. Perilipin 5 regulates the formation and stabilization of cardiac LDs, and it promotes cardiac steatosis without major heart function impairment.-Wang, H., U. Sreenivasan, D-W. Gong, K. A. O'Connell, E. R. Dabkowski, P. A. Hecker, N. Ionica, M. Konig, A. Mahurkar, Y. Sun, W. C. Stanley, and C. Sztalryd. Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J. Lipid Res. 2013. 54: 953-965.
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