Journal
JOURNAL OF LIPID RESEARCH
Volume 54, Issue 10, Pages 2866-2873Publisher
ELSEVIER
DOI: 10.1194/jlr.M041590
Keywords
omega-3 polyunsaturated fatty acids; fatty acid biosynthesis; SREBF1; ACACA; ACLY; interindividual variability
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP229488]
- Fonds de recherche en sante du Quebec (FRQS)
- CIHR [201210GSD-304012-190387, 200810BFE]
- Tier 1 Canada Research Chair in Genomics Applied to Nutrition and Health
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Interindividual variability in the response of plasma triglyceride concentrations (TG) following fish oil consumption has been observed. Our objective was to examine the associations between single-nucleotide polymorphisms (SNPs) within genes encoding proteins involved in de novo lipogenesis and the relative change in plasma TG levels following a fish oil supplementation. Two hundred and eight participants were recruited in the greater Quebec City area. The participants completed a six-week fish oil supplementation (5 g fish oil/day: 1.9-2.2 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid. SNPs within SREBF1, ACLY, and ACACA genes were genotyped using TAQMAN methodology. After correction for multiple comparison, only two SNPs, rs8071753 (ACLY) and rs1714987 (ACACA), were associated with the relative change in plasma TG concentrations (P = 0.004 and P = 0.005, respectively). These two SNPs explained 7.73% of the variance in plasma TG relative change following fish oil consumption. Genotype frequencies of rs8071753 according to the TG response groups (responders versus nonresponders) were different (P = 0.02).(jlr) We conclude that the presence of certain SNPs within genes, such as ACLY and ACACA, encoding proteins involved in de novo lipogenesis seem to influence the plasma TG response following fish oil consumption.
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