Journal
JOURNAL OF LIPID RESEARCH
Volume 53, Issue 8, Pages 1430-1436Publisher
ELSEVIER
DOI: 10.1194/jlr.R024299
Keywords
lipolysis; triacylglycerol; synthesis
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Funding
- Max Planck Society
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The fruit fly Drosophila melanogaster is an emerging model system in lipid metabolism research. Lipid droplets are omnipresent and dynamically regulated organelles found in various cell types throughout the complex life cycle of this insect. The vital importance of lipid droplets as energy resources and storage compartments for lipoanabolic components has recently attracted research attention to the basic enzymatic machinery, which controls the delicate balance between triacylglycerol deposition and mobilization in flies.(jlr) This review aims to present current insights in experimentally supported and inferred biological functions of lipogenic and lipolytic enzymes as well as regulatory proteins, which control the lipid droplet-based storage fat turnover in Drosophila.-Kuhnlein, R. P. Lipid droplet-based storage fat metabolism in Drosophila. J. Lipid Res. 2012. 53: 1430-1436.
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